The Orai-1 and STIM-1 Complex Controls Human Dendritic Cell Maturation

The Orai-1 and STIM-1 Complex Controls Human Dendritic Cell Maturation

Ca(2+) signaling plays an important role in the function of dendritic cells (DC), the professional antigen presenting cells. Here, we described the role of Calcium released activated (CRAC) channels in the maturation and cytokine secretion of human DC. Recent works identified STIM1 and Orai1 in human T lymphocytes as essential for CRAC channel activation. We investigated Ca(2+) signaling in hum...

Dendritic Cell Maturation Controls

STIM and Orai in hemostasis and thrombosis.

At sites of vascular injury, platelets rapidly adhere to the exposed subendothelial extracellular matrix, become activated and, together with the coagulation system, form a plug that seals the lesion. This process is essential to prevent blood loss, however, under pathological conditions it may lead to vessel occlusion. Agonist-induced elevation of intracellular Ca(2+) levels is essential for p...

The calcium store sensor , STIM 1 , recipro - cally controls

Question: Why do excitable cells express store-operated Ca channels and nonexcitable cells express voltage-gated Ca channels (VGCCs)? Background: Ca release-activated Ca (CRAC) Orai channels increase intracellular Ca concentrations in response to depletion of endoplasmic reticulum (ER) Ca stores via a stromal interaction molecule 1 (STIM1)-dependent mechanism. VGCCs, suchas Cav1.2 channels, inc...

Molecular mechanisms of STIM/Orai communication.

Ca(2+)entry into the cell via store-operated Ca(2+)release-activated Ca(2+)(CRAC) channels triggers diverse signaling cascades that affect cellular processes like cell growth, gene regulation, secretion, and cell death. These store-operated Ca(2+)channels open after depletion of intracellular Ca(2+)stores, and their main features are fully reconstituted by the two molecular key players: the str...